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In 1500, who murdered Lucrezia Borgia's second husband?

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Her first marriage (1492) to Giovanni Sforza of Pesaro was annulled in 1497, and she was married to Alfonso of Aragón, illegitimate son of Alfonso II of Naples. Her brother, Cesare Borgia , had her second husband murdered in 1500, and, in 1501, Lucrezia was married to Alfonso d'Este, who became duke of Ferrara in 1505.

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