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[Addison's disease is] brought about by atrophy of the outer layer, or cortex, of the adrenal gland ; it is also called chronic adrenocortical insufficiency. The deterioration of this tissue causes a decrease in the secretion of steroid hormones, many of which are necessary for the maintenance of life. In many cases the cause of the wasting process is not known; in others the predominant cause is the formation and infiltration of tumors, inflammatory disease, or surgery.
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