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Individuals may contain the A, B, or both A and B antigenic substances, or else lack these substances (type O). In the ABO system an individual who lacks one or more of these antigens will spontaneously develop the corresponding antibodies (agglutinins) shortly after birth. Thus a person with A type blood will naturally produce anti-B agglutinins, a person with B blood will produce anti-A agglutinins, and a person with O blood will produce anti-A and anti-B agglutinins; but a person with AB blood will not produce any agglutinins in this blood group system.
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