When was Nagasaki opened to foreign trade?

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Nagasaki was gradually reopened to general foreign trade during the 1850s. Long a center of Christianity, the city had until 1945 Japan's largest Roman Catholic cathedral. During World War II, on Aug. 9, 1945, Nagasaki became the target of the second atomic bomb ever detonated on a populated area; about 75,000 people were killed or wounded, and more than one third of the city was devastated.

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