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Finally, in 1875, Oscar Hertwig's principle of the universality of fertilization in sexual reproduction confirmed the transmission of hereditary material through the two sex cells. August Weismann's theory of germ plasm continuity (1892) established that the germ (sex) cells are set apart from other body cells early in embryonic development and thus that only changes in the germ plasm, and not influences on the adult body, can affect the characteristics of future generations. In 1900 the neglected work of Gregor Mendel was rediscovered and the first scientific laws for the mechanisms of hereditary were presented. These, correlating with the microscopic and experimental observations of the behavior of chromosomes and reproductive cells and later with the biochemical analyses of genes and their products, provided the basis for modern studies.
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