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During prophase the two chromatids remain attached to one another at a region called the centromere, but each contracts into a compact tightly coiled body; the nucleolus and, in most cases, the nuclear envelope break down and disappear. Also during prophase the spindle begins to form. In animal cells the centrioles separate and move apart, and radiating bundles of fibers, called asters, appear around them. Some sets of fiber run from one centriole to the other; these are the spindle fibers. In plant cells the spindle forms without centrioles.
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