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What are some causes of abnormal fatigue?

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In some instances this abnormal fatigue may be associated with systemic disorders such as anemia, a deficiency of protein or oxygen in the blood, addiction to drugs, increased or decreased function of the endocrine glands, or kidney disease in which there is a large accumulation of waste products. If excessive fatigue occurs over a prolonged period, exhaustion (marked loss of vital and nervous power) may result. In most persons with chronic fatigue, however, the condition seems to be associated with bipolar disorder. Thorough medical and psychiatric examination may be required ...

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