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Spontaneous abortion during the last two thirds of pregnancy is more likely to be due to maternal factors, for example abnormalities of the cervix or uterus, insufficient progesterone , sexually transmitted diseases that affect the genital tract, endocrine dysfunction (as in hypothyroidism and diabetes mellitus), or severe emotional trauma. Immunological reactions, in which maternal antibodies mistake the fetus for foreign tissue, have been implicated in recurrent, or habitual spontaneous abortions.
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